AIMRC Seminar: Prospects and Perils of in Vivo Genome Engineering

AIMRC Seminar: Prospects and Perils of in Vivo Genome Engineering
Photo Submitted

The Arkansas Integrative Metabolic Research Center will host Christopher Nelson, 21st Century Assistant Professor of Biomedical Engineering at the U of A, at 12:55 p.m. Wednesday Sept. 20, in BELL 2267, when Nelson will discuss his work on adapting CRISPR-based tools for correcting genetic diseases.

In vivo genome engineering stands to improve the treatment of the molecular basis of disease. Clinical trials are underway to treat genetic diseases like sickle cell anemia, inherited blindness, amyloidosis and others. Yet significant challenges prevent the broad adoption of genome engineering. Nelson will present his work adapting CRISPR-based tools for correcting genetic diseases. He will highlight immune-related challenges and unintentional genomic and transcriptomic changes made with conventional gene editing. The Nelson Lab is adapting new tools for more precise gene editing and alternate delivery schemes that may bypass the immune-related challenges of viral-based delivery. Finally, Nelson will discuss developing tools for precise transcriptomic control which will have broad utility as a therapeutic and as a basic science tool for metabolic research.

Christopher Nelson obtained a degree in biological engineering from the U of A in 2009. He then moved to Vanderbilt University to develop non-viral gene delivery vehicles with Craig Duvall. After obtaining his Ph.D., he developed tools for in vivo genome engineering with CRISPR with Charles Gersbach at Duke University. Nelson then returned to the U of A in 2019 as an assistant professor of biomedical engineering with an NIH Pathway to Independence award. The Nelson lab focuses on developing new approaches for genome engineering to overcome the delivery limitations and is specifically interested in developing tools for gene editing and gene regulation in muscle and in regenerative medicine applications.

If you are unable to attend the seminar in person, you are welcome to join via Zoom.

Please contact Kimberley Fuller at for more information.

This event is supported by the NIGMS of the National Institutes of Health under Award Number P20GM139768. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.



Serving Arkansans: Chancellor Robinson Visits Community Colleges to Support Transfer Students

U of A officials visited U of A Community College at Hope-Texarkana, U of A Community College at Morrilton, U of A Pulaski Technical College and National Park College in Hot Springs.

Agricultural Experiment Station Awards Four Outstanding Faculty and Staff With RoPE Awards

Nathaniel Moss, Jiamei Li, Tina Poseno and Ryan Dickson were recognized by the Arkansas Agricultural Experiment Station for exceptional performance in the experiment station's mission and goals.

Celebrate the 10th Annual Native Youth in Food and Agriculture Leadership Summit Cohort Today

The Indigenous Food and Agriculture Initiative at the U of A School of Law welcomed its 10th class of Native Youth in Food and Agriculture Leadership Summit participants to campus.

Harry Patrinos Named Head of Department of Education Reform

Patrinos, an internationally recognized expert in K-12 education policy, has been named head of the Department of Education Reform and 21st Century Endowed Chair in Education Policy.

Mark Your Calendar for the Staples Supplier Connection Event July 29

The U of A Business Services Procurement Team, together with Staples, would like to invite U of A faculty and staff members to a Supplier Connection Event in the Connections Lounge of the Arkansas Union.

News Daily