Biomedical Engineering Professor Receives NSF Award to Support Research in Cellular Biomanufacturing

Rebekah Samsonraj
University Relations

Rebekah Samsonraj

Rebekah Margaret Samsonraj, assistant professor in the Department of Biomedical Engineering, has received a $466,266 grant from the National Science Foundation for research in future biomanufacturing of stem cell-derived therapeutics.

The goal of the project is to understand mechanisms of biophysical modulation of mesenchymal stem cells (MSCs) to enhance the secretion of bioactive extracellular vesicles that can mediate tissue repair and regeneration. A major bottleneck in MSC-derived extracellular vesicles biomanufacturing is their scalability during product development to achieve clinically relevant doses. Current practices rely on invasive manipulations to cells and culture conditions which have either damaging implications on the final product or incur high costs and operate at small scales making them less viable for best-practice manufacturing.

This innovative study will improve MSC-derived extracellular vesicles production through noninvasive modulations of MSCs feasible for large-scale manufacturing. This NSF Future Manufacturing Seed Grant will allow identification of cellular responses to biophysical modulations and evaluate improvements to overall secretome, EV production, and functionality. The study will not only add new fundamental knowledge on mechanotransduction in MSCs, but also provide functional evidence for overcoming large-scale manufacturing challenges in MSC production.

"I'm grateful to receive this competitive grant from NSF to study the fascinating characteristics of MSCs which can be harnessed for accelerating novel cell-based therapies. We're thrilled to receive federal support to advance our innovative research on MSCs. This is an outcome of tremendous efforts by our team, and we are looking forward to impactful results", says Samsonraj. The project will train and develop a strong and diverse future biomanufacturing workforce, having wide-reaching impacts on education, science and engineering, and the U.S economy.

Samsonraj has lead research efforts in the field of MSC-based cellular therapy and best-in-class MSC manufacturing since her doctoral studies. She was recently named 'MSC Rising Star' by Rooster Bio, a leading cell manufacturing industry. Her young and growing laboratory — the Cellular Therapy and Biomanufacturing Lab — collaborates with multiple cell experts across the nation and is well-poised to take their science closer to clinical implementation and commercialization.

Raj R. Rao, professor and head of biomedical engineering, said that the manufacturing aspect of this work is an important step to help move theoretical research toward commercialization. "I am excited about Dr. Samsonraj's plan for this research," he said. "The more research activities move toward production and commercialization of real-world therapies, the better for consumers in need of the products and the better for the economy through higher-paying employment opportunities in the workforce."

More details about ongoing research in cell-based therapies and regenerative medicine in the Department of Biomedical Engineering can be found on the regenerative research page.

Contacts

Rebekah Samsonraj, assistant professor
Department of Biomedical Engineering
479-575-8640, rmsamson@uark.edu

Christin Finney, digital communications specialist
College of Engineering
479-575-4173, crn002@uark.edu

Headlines

Founding Faculty Member Takes Helm in Department of Biomedical Engineering

Jeffrey Wolchok, also well-known for his strong record as a student mentor, will assume his new duties July 1.

New 'International in NWA' Podcast Available

The episode, titled "Papers Please! The Importance of Keeping Immigration Documents," features a conversation with Adam Cohen, an attorney in the Memphis office of Siskind Susser.

Angela Oxford to Leave the University, but Continues With Community Engagement

There will be a "see you later" drop-in reception on July 12 from 3 p.m. - 5 p.m. in the Center for Community Engagement office in the Arkansas Union A643.

Did Biosecurity Lessons in 2015 Curb the 2022 Bird Flu Outbreak Deaths? An Arkansas Agricultural Economist Has a Clue.

Jada Thompson, assistant professor of agribusiness in the Department of Agricultural Economics and Agribusiness, said one factor indicates proper biosecurity may have had a significant impact.

Spring 2022 Chancellor's and Deans' Lists Now Available

Students with a 4.0 GPA qualify for the Chancellor’s List; students with averages between 3.75 and 4.0 are named to the Dean’s List.

News Daily