How do our brain, nose, and mouth work together to generate the flavor of food and drink? When flavor perception goes wrong, can this play a role in diseases like obesity?

The sense of smell is very important for perceiving flavor, largely because of odors that originate in the mouth and are exhaled through the nose via the back of the throat in a process called retronasal olfaction. However, the detailed mechanisms of how retronasal odors get encoded in the brain are poorly understood. The Shew Lab at University of Arkansas has put together a team from across the United States to study these phenomena. The National Science Foundation has funded the research with a total of $923,000 over three years, more than half of which will fund the U of A part of the team.  

The researchers combine direct measurements of the brain in action together with computer simulations of air flow through the nose and neural networks. They are testing the idea that different forces in the nose caused by reversing airflow through the nasal cavity are responsible for how the brain distinguishes exhaled retronasal odors from inhaled odors. The research will heavily involve students and will also develop an educational video game together with UA Tesseract Center aimed at introducing players to basic concepts of neurobiology and cognitive neuroscience.

Experiments done at the University of Arkansas will be lead by associate professor Woodrow Shew and postdoctoral fellow Shree Gautam.  Shew and Gautam are in the Department of Physics and affiliated with the UA Integrative Systems Neuroscience group.

To gain deeper insight on the experiments, computer model neural networks will be developed by Cheng Ly, an associate professor in the Department of Statistical Sciences and Operations Research at Virginia Commonwealth University. Additional computer simulations of air flow through the nasal cavity (see picture) will be done by Andrea Bareiro, an assistant professor of mathematics at Southern Methodist University. The complex structure of the nasal cavity will be precisely determined using the facilities of the recently established microCT Imaging Consortium for Research and Outreach at the U of A.