Research Provides Important Insight on the Brain-Body Connection

Woodrow Shew
Photo by University Relations

Woodrow Shew

FAYETTEVILLE, Ark. – A study conducted by University of Arkansas researchers reveals that neurons in the motor cortex of the brain exhibit an unexpected division of labor, a finding that could help scientists understand how the brain controls the body and provide insight on certain neurological disorders.

The researchers studied the neurons in the motor cortex of rats and found that they fall into two groups: “externally focused” neurons that communicate with and control different parts of the body and “internally focused” neurons that only communicate with each other and don’t send signals to other parts of the body. The researchers also found that when they increased inhibition of neurons in the motor cortex, the externally focused neurons switched to internally focused.

“Alterations in inhibitory signaling are implicated in numerous brain disorders,” explained Woodrow Shew, associate professor of physics. “When we increased inhibition in the motor cortex, those neurons responsible for controlling the body become more internally oriented. This means that the signals that are sent to the muscles from the motor cortex might be corrupted by the ‘messy’ internal signals that are normally not present.”

Rett Syndrome, a rare but severe neurological disorder, is one of the brain disorders associated with an increase in inhibition. Shew plans to further research the implications of these findings for Rett Syndrome.

Shew, along with U of A graduate students Patrick Kells, Leila Fakhraei and Jingwen Li and postdoctoral researcher Shree Hair Gautam, published their results in Nature Communications.

About the J. William Fulbright College of Arts and Sciences: The J. William Fulbright College of Arts and Sciences is the largest and most academically diverse unit on campus with three schools, 16 departments and 43 academic programs and research centers. The college provides the core curriculum for all University of Arkansas students and is named for J. William Fulbright, former university president and longtime U.S. senator.

About the University of Arkansas: The University of Arkansas provides an internationally competitive education for undergraduate and graduate students in more than 200 academic programs. The university contributes new knowledge, economic development, basic and applied research, and creative activity while also providing service to academic and professional disciplines. The Carnegie Foundation classifies the University of Arkansas among fewer than 2.7 percent of universities in America that have the highest level of research activity. U.S. News & World Report ranks the University of Arkansas among its top American public research universities. Founded in 1871, the University of Arkansas comprises 10 colleges and schools and maintains a low student-to-faculty ratio that promotes personal attention and close mentoring.

Contacts

Woodrow Shew, associate professor of physics
J. William Fulbright College of Arts and Sciences
479-575-2506, shew@uark.edu

Camilla Shumaker, director of science and research communications
University Relations
479-575-7422, camillas@uark.edu

Headlines

The World as a Classroom: The Executive M.B.A. Program at U of A

The program, offered through the Sam M. Walton College of Business, blends online learning with face-to-face interaction and applied studies in a real-time international immersion trip.

Keri Blakinger, Author of 'Corrections in Ink,' to Speak at Fayetteville Public Library April 22

Blakinger, an award-winning journalist now at the Los Angeles Times, will talk about her memoir and her work as a reporter at 6 p.m. April 22 at the Fayetteville Public Library's Walker Community Room.

Visit With University Libraries and Pat Walker Health Center's Medical Services at Carnival Today

Employees are invited to meet fellow workers from units across campus including the University Libraries and the Pat Walker Health Center at today's Making Your Day Work Carnival at the Arkansas Union.

Farewell Reception April 3 for Fulbright College's Lisa Summerford

The campus community is invited to celebrate Summerford's achievements and to wish her well during a drop-in retirement reception from 3:30-5 p.m. Wednesday, April 3, in the Fulbright College Dean's Office in Old Main 523.

Rachel McGathy Retiring After 25 Years

There will be a reception to celebrate McGathy's retirement from 2:30-4:30 p.m. Friday, March 29, in the downstairs breakroom at Uptown East.

News Daily