Nanowired Drugs Could Treat Patients With Parkinson's or Alzheimer's
FAYETTEVILLE, Ark. – Millions of Americans suffer from neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Researchers have identified promising new treatments, such as cerebrolysin, but current clinical approaches are ineffective because critical concentrations of the drug dissipate within the body before reaching the brain and central nervous system.
To address this problem, researchers have focused on various delivery vehicles for sustained and targeted drug release. An effective, targeted approach would eliminate the need for inefficient, high dosages that cause adverse side effects.
In recent years, biomedical engineers have experimented with nanomaterials as an approach to targeted delivery. Under the direction of Ryan Tian, associate professor of chemistry at the University of Arkansas, doctoral student Asya Ozkizilcik has improved the nanowiring of drugs for an international team of researchers who are working on a new method for treating neurodegenerative diseases.
This week, at Neuroscience 2017, the annual meeting of the Society for Neuroscience, held in Washington, D.C., Ozkizilcik, on behalf of the international research team, delivered two presentations about nanowired delivery of cerebrolysin in neuropathological models of Alzheimer’s and Parkinson’s diseases. The team’s research was selected as newsworthy from a pool of nearly 14,000 abstracts. Their research was also included in the Society’s Hot Topics book.
Ozkizilcik worked with titanate, a bioceramic material made of titanium dioxide. Titanate has many advantages. Its nanowires are chemically inert and therefore do not interact with biological components. In addition to biocompatibility, the nanowires are resistant to corrosion in biological fluids, which is ideal for sustained, in vivo drug release without harming cells or tissues.
Ozkizilcik made the titanate nanowires in an autoclave treatment and then loaded cerebrolysin onto the nanowires. Though detailed mechanisms are unclear, the nanoparticles may prolong the intact delivery of cerebrolysin all the way to blood-brain barrier, where high concentrations of the drug are then released into the brain. The drug’s efficacy was tested on rat models with co-administration of mesenchymal stem cells. Mesenchymal stem cells have been used for developing therapeutics for various autoimmune and other diseases.
Ozkizilcik’s research is part of the international team’s broader goal of finding a more effective treatment for neurodegenerative diseases such as Alzheimer’s and Parkinson’s. The international team has also demonstrated efficacy of this treatment on a Parkinson’s disease model after traumatic brain injury.
“We believe titanate nanowires could be considered as potential drug delivery tools for neurodegenerative diseases and may be translated into clinical use in future,” Ozkizilcik said.
Asya Ozkizilcik, doctoral student
Department of Biomedical Engineering
Ryan Tian, associate professor
Department of Chemistry and Biochemistry
Matt McGowan, science and research communications officer
Chancellor Joe Steinmetz and Big Red wish the U of A community a relaxing and safe Spring Break this week.
The Arkansas Alpha chapter of Tau Beta Pi received the Chapter Excellence Award, the Chapter Project Award, and Honorable Mention for the R.H. Nagel Most Improved Chapter Award.
The Teacher Education Career Fair is for all students seeking employment opportunities within the education industry. It will be from 3:30-5:30 p.m. April 2 at the Arkansas Union Verizon Ballroom.
The University of Arkansas Computer Store, located at 616 N. Garland Ave., is offering a limited time deal on the Microsoft Surface Pro. Buy in-store and save money with the educational bundle.
The UARK Human Library will utilize interactive storytelling as a platform to learn about the experiences and perspectives of individuals with compelling personal narratives. Sign up now.